The Grand Strand was recognized for its family-friendly atmosphere.
The list of nominees also included Cabo San Lucas, Mexico; Cancun; Daytona Beach, Fla.; and Montego Bay, Jamaica.
"The Myrtle Beach area prides itself on being an affordable, world-class family beach destination that visitors can enjoy year-round," said Brad Dean, president and CEO of the Myrtle Beach Area Chamber of Commerce. "We are grateful for all who voted in this poll, and are excited to welcome returning guests and first-time visitors to the Myrtle Area this spring, summer and fall."
Below are the rankings for favorite spring break destination, according to the USA Today 10Best poll:
1. Myrtle Beach, S.C.
2. Cabo San Lucas, Mexico
3. Cocoa Beach, Fla.
4. Atlantic Beach, N.C.
5. Punta Cana, Dominican Republic
6. Daytona Beach, Fla.
7. Rio Grande, Puerto Rico
8. Panama City Beach, Fla.
10. South Padre Island, Texas